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["2022年度安徽医科大学研究生科研与实践创新项目立项名单"]
["序号","项目名称","项目编号","主持人"]
[{"$nulls":3},"学号","姓名","培养单位名称","专业","攻读层次"]
[1,"MANF与Notch2相互作用促进肝细胞向胆管癌转化","YJS20230001",2146010016,"梅琼","基础医学院","药理学","博士"]
[2,"心肌尔康依赖NKD2调节Wnt/β-catenin信号通路抑制内皮间质化缓解心肌梗死诱导的心力衰竭","YJS20230002",2246010024,"蔡伟伟","基础医学院","药理学","博士"]
[3,"G蛋白偶联受体107介导内吞细胞外基质四型胶原蛋白而促进乳腺癌侵袭和转移","YJS20230003",2246010019,"徐如月","基础医学院","医学生物化学与分子生物学","博士"]
[4,"TBPL2在卵母细胞成熟中作用及其机制研究","YJS20230004",2146010015,"李蔷薇","基础医学院","医学生物化学与分子生物学","博士"]
[5,"GR-Mettl3 介导的胎盘 Pparα 表达降低在孕期母体强的松暴露所致胎儿生长受限中的作用及其 m6A 修饰机制","YJS20230005",2146010042,"常伟","公共卫生学院","卫生毒理学","博士"]
[6,"线粒体功能障碍介导的ETS2 m6A上调在砷诱发小鼠精原干细胞衰老中的作用","YJS20230006",2146010043,"张潇逸","公共卫生学院","卫生毒理学","博士"]
[7,"长链非编码RNA m6A甲基化修饰在类风湿关节炎中的作用及机制研究","YJS20230007",2146010029,"陶莎莎","公共卫生学院","流行病与卫生统计学","博士"]
[8,"童年期不良经历暴露模式与端粒相关基因风险评分交互影响大学生抑郁症状发展轨迹的队列研究","YJS20230008",2246010040,"李书琴","公共卫生学院","儿少卫生与妇幼保健学","博士"]
[9,"纳米材料包被供体T细胞通过免疫隔离抑制共刺激信号缓解移植物抗宿主病并保留移植物抗肿瘤效应","YJS20230009",2146010048,"王涵","临床药理研究所","药理学","博士"]
[10,"CD36介导的巨噬细胞自噬加重肝纤维化进程","YJS20230010",2146010053,"李良云","药学院","药理学","博士"]
[11,"温敏性水负载具有SOD及CAT酶活性的铜基纳米材料促进急性创面愈合","YJS20230011",2146010074,"金煦","第一临床医学院（第一附属医院）","外科学（烧伤）","博士"]
[12,"大脑功能同伦的遗传机制：\n一项结合转录组和动态功能连接的研究","YJS20230012",2146010192,"赵晗","第一临床医学院（第一附属医院）","放射影像学","博士"]
[13,"负载含姜黄素/肝细胞生长因子的GelMA/壳聚糖双组分水凝胶的3D打印阵列微针促进创面愈合的研究","YJS20230013",2246010164,"邢丹蕾","第一临床医学院（第一附属医院）","外科学（烧伤）","博士"]
[14,"MBP通过激活mTORC1-HMGCS1-IGF2BP3信号通路促进支气管哮喘气道重塑的机制研究","YJS20230014",2246010064,"陈旭","第一临床医学院（第一附属医院）","老年医学","博士"]
[15,"基于ROS响应的多肽卡马西平偶联体前药在癫痫治疗中的应用","YJS20230015",2246010068,"孟倩","第一临床医学院（第一附属医院）","神经病学","博士"]
[16,"新型METTL3抑制剂的筛选及其对急性髓系白血病小鼠模型抗肿瘤作用和机制研究","YJS20230016",2246010091,"焦长青","第一临床医学院（第一附属医院）","内科学（血液病）","博士"]
[17,"基于脑电图指导的精确麻醉管理对老年食管癌手术患者预后以及应激反应的影响","YJS20230017",2246010186,"季东","第一临床医学院（第一附属医院）","麻醉学","博士"]
[18,"人类梭状回功能梯度的研究","YJS20230018",2246010204,"陈静瑶","第一临床医学院（第一附属医院）","放射影像学","博士"]
[19,"富马酸二甲酯通过调控NRF2-Sting途径改善线粒体稳态治疗放射性肺损伤的研究","YJS20230019",2246010201,"桂仲璇","第一临床医学院（第一附属医院）","肿瘤学","博士"]
[20,"基于蛋白质组学研究横向骨搬运促下肢微血管增殖的作用及机制","YJS20230020",2146010158,"孔令超","第一临床医学院（第一附属医院）","骨科学","博士"]
[21,"骨关节炎滑膜相关磷酸化蛋白调控机制研究","YJS20230021",2146010163,"张珂","第一临床医学院（第一附属医院）","骨科学","博士"]
[22,"高脂饮食通过机械敏感离子通道调节胃泌素表达水平诱导小鼠胃黏膜萎缩和癌前病变机制研究","YJS20230022",2246010143,"杨博","第一临床医学院（第一附属医院）","外科学（普外）","博士"]
[23,"过氧化物还原酶2（PRDX2）相关ceRNA调控网络在糖尿病伤口愈合中的作用及其机制研究","YJS20230023",2246010106,"唐颖","第一临床医学院（第一附属医院）","内科学（内分泌与代谢病）","博士"]
[24,"基于专病数据库、计算病理学和影像组学构建肝细胞癌术后早期复发的多模态预测模型的研究","YJS20230024",2146010132,"陈子祥","第一临床医学院（第一附属医院）","外科学（普外）","博士"]
[25,"（慢性）前列腺炎样症状的致病因素调查-基于中国人群的前瞻性队列研究","YJS20230025",2246010076,"金晨","第一临床医学院（第一附属医院）","外科学（泌尿外）","博士"]
[26,"新型布尼亚病毒感染人肝细胞的分子机制和可视化过程","YJS20230026",2246010193,"张吟","第一临床医学院（第一附属医院）","临床检验诊断学","博士"]
[27,"基于CRISPR／Cas9全基因组文库筛选发现IARS2抑制头颈部鳞状细胞癌铁死亡的作用及机制研究","YJS20230027",2146010172,"丁召","第一临床医学院（第一附属医院）","耳鼻咽喉科学","博士"]
[28,"褪黑素通过Sestrin2/Nrf2信号轴缓解心肌线粒体损伤在慢阻肺相关心功能不全中的分子机制研究","YJS20230028",2246010092,"张大卫","第一临床医学院（第一附属医院）","内科学（呼吸系病）","博士"]
[29,"氯化三苯基锡在卵母细胞和早期胚胎发育中的影响及相关机制探究","YJS20230029",2246010175,"马聪","第一临床医学院（第一附属医院）","妇产科学","博士"]
[30,"基于Wnt/β-catenin信号通路探讨TMEM88调控重症急性胰腺炎中炎症因子分泌的功能和机制研究","YJS20230030",2246010222,"孙远松","第二临床医学院（第二附属医院）","重症医学","博士"]
[31,"SRRM2蛋白在血液肿瘤中的表达及其靶向CAR-T细胞治疗多发性骨髓瘤的实验研究","YJS20230031",2146010206,"郭进京","第二临床医学院（第二附属医院）","内科学（血液病）","博士"]
[32,"Diosmin调控脂肪酸结合蛋白4在肾间质纤维化中的作用及机制研究","YJS20230032",2146010205,"赵文曼","第二临床医学院（第二附属医院）","内科学（肾病）","博士"]
[33,"槲皮素通过调节PI3K/Akt信号通路改善MK-801诱导精神分裂症样小鼠的认知损害研究","YJS20230033",2146010221,"杨亚婷","巢湖临床医学院（附属巢湖医院）","精神病与精神卫生学","博士"]
[34,"ASAP2通过调节线粒体能量代谢促进\n胃癌发生发展的作用和机制研究","YJS20230034",2145010043,"段江玲","基础医学院","免疫学","硕士"]
[35,"右美托咪定作用于PVHOXT神经细胞调控睡眠节律的机制研究","YJS20230035",2145010003,"张颖","基础医学院","生理学","硕士"]
[36,"NRF2-CARM1 介导细胞糖代谢重编程促进胃癌发展的机制研究","YJS20230036",2145010080,"平苗苗","基础医学院","病理学与病理生理学","硕士"]
[37,"单核-巨噬细胞来源的神经营养因子MANF通过Msr1调控巨噬细胞活化促进非酒精性脂肪肝进展","YJS20230037",2145010042,"张丽君","基础医学院","人体解剖与组织胚胎学","硕士"]
[38,"人脊髓神经干细胞通过轴突再生治疗脊髓损伤的研究","YJS20230038","2145010040","王馨萌","基础医学院","人体解剖与组织胚胎学","硕士"]
[39,"自身免疫调节因子Aire通过液液相分离来调控其转录活性","YJS20230039",2145010057,"盛梦飞","基础医学院","病原\n生物学","硕士"]
[40,"CLIC4通过TRIM25-ATP2A2轴促进食管鳞状细胞癌的发生","YJS20230040",2145010229,"范旭","生命科学学院","细胞生物学","硕士"]
[41,"磁共振全息射频发射场电特性成像研究","YJS20230041",2245012413,"任印豪","生物医学工程学院","生物医学工程","硕士"]
[42,"可溶性微针搭载锰盐和替莫唑胺用于黑色素瘤的化学免疫协同治疗","YJS20230042",2145012261,"蒋业春","生物医学工程学院","电子信息（生物医学工程方向）","硕士"]
[43,"肠道菌群定植改变在围生期阿莫西林暴露加速果糖诱导胰岛素抵抗中的作用","YJS20230043",2145010348,"董鑫","公共卫生学院","卫生毒理学","硕士"]
[44,"Parkin线粒体转位在镉抑制睾丸睾酮合成中的作用","YJS20230044",2145010497,"汪甜甜","公共卫生学院","公共卫生（卫生毒理学）","硕士"]
[45,"补体片段C5a介导气道上皮细胞HMGB1/RAGE信号通路在纳米二氧化硅致肺纤维化中的作用研究","YJS20230045",2145010314,"周思凡","公共卫生学院","劳动卫生与环境卫生学","硕士"]
[46,"Cyr61低羟甲基化在孕期1-硝基芘暴露所致胎盘血管形成障碍中的作用","YJS20230046",2145010487,"陈晓希","公共卫生学院","公共卫生（卫生毒理学）","硕士"]
[47,"生物钟在煤尘暴露对煤矿工人肺功能影响中的作用","YJS20230047",2145010311,"潘海泓","公共卫生学院","劳动卫生与环境卫生学","硕士"]
[48,"膳食大豆异黄酮摄入及其肠道菌群依赖性代谢物雌马酚与动脉硬化的横断面研究","YJS20230048",2145010436,"梁绍娴","公共卫生学院","公共卫生（营养）","硕士"]
[49,"胎盘雌激素受体（ERα/ERβ）上调在双酚A及其替代物致胎儿生长受限（FGR）的作用","YJS20230049",2145010456,"关添月","公共卫生学院","公共卫生（儿少方向）","硕士"]
[50,"卡培他滨所致手足综合征影响触觉感受的作用机制研究","YJS20230050",2145010355,"芮晨","公共卫生学院","卫生毒理学","硕士"]
[51,"生命历程视角下童年不良经历对生育意愿的影响研究","YJS20230051",2245010572,"王青","卫生管理学院","社会医学与卫生事业管理","硕士"]
[52,"合肥市公共卫生应急协同治理评价指标体系研究 ","YJS20230052",2145010572,"郑信","卫生管理学院","社会医学与卫生事业管理","硕士"]
[53,"超高分子聚丙烯酸钠脱矿联用铒激光提高牙本质粘接耐久性","YJS20230053",2145010605,"钟琦","口腔医学院（附属口腔医院）","口腔临床医学","硕士"]
[54,"SCD1/FoxO1通路调控髁突软骨细胞自噬参与颞下颌关节骨关节炎的机制研究","YJS20230054",2145010595,"沈振国","口腔医学院（附属口腔医院）","口腔临床医学","硕士"]
[55,"GRK2激活PPARγ信号抑制类风湿关节炎滑膜巨噬细胞活化的机制研究","YJS20230055",2245010694,"王露萍","临床药理研究所","药理学","硕士"]
[56,"PCOLCE通过PI3K/ATK信号通路抑制类风湿性关节炎滑膜中巨噬细胞的炎症反应","YJS20230056",2145010743,"杨影莉","药学院","药理学","硕士"]
[57,"TRPM7调控PKCα-HuR-Rac1轴促进类风湿关节炎成纤维样滑膜细胞异常活化的作用及其机制","YJS20230057",2145010726,"林怡","药学院","药理学","硕士"]
[58,"IL-22重组蛋白自组装成缓释水凝胶在酒精性肝病中的应用及其机制研究","YJS20230058",2245010895,"杨大帅","药学院","药学","硕士"]
[59,"转录因子STAT3在急性肾损伤中的功能与机制探究","YJS20230059",2145010722,"纪明璐","药学院","药理学","硕士"]
[60,"清肾颗粒调节树突细胞代谢抗肾纤维化机制研究","YJS20230060",2145010752,"周文静","药学院","药理学","硕士"]
[61,"红医精神思想政治教育价值研究","YJS20230061",2145010864,"吴宇晴","马克思主义学院","思想政治教育","硕士"]
[62,"经皮耳迷走神经刺激提高抑郁症快感缺失个体追求奖赏动机研究","YJS20230062",2145010885,"郭阳","精神卫生与心理科学学院","应用心理","硕士"]
[63,"精神分裂症基于拓扑的工作记忆损伤机制及干预研究","YJS20230063",2145010897,"唐彦","精神卫生与心理科学学院","精神病与精神卫生学","硕士"]
[64,"menin对肺腺癌细胞中PD-L1的调控及作用机制研究","YJS20230064",2145010964,"张存存","护理学院","护理学","硕士"]
[65,"非小细胞肺癌患者围术期运动依从性影响因素及作用路径研究","YJS20230065",2145011032,"张亚文","护理学院","护理","硕士"]
[66,"老年糖尿病患者跌倒恐惧和生活空间移动性相关分析及临床预测模型构建与验证","YJS20230066",2145011026,"张海燕","护理学院","护理","硕士"]
[67,"坐骨神经电刺激联合BWSTT对不完全性脊髓损伤大鼠神经功能及BDNF-TrkB表达的影响","YJS20230067",2145011209,"徐青亲","第一临床医学院（第一附属医院）","康复医学与理疗学","硕士"]
[68,"免疫原性细胞死亡相关基因识别子宫内膜癌的预后和免疫治疗反应的研究","YJS20230068",2145011175,"刘振冉","第一临床医学院（第一附属医院）","妇产科学","硕士"]
[69,"楔前叶的功能梯度研究","YJS20230069",2145011501,"江平","第一临床医学院（第一附属医院）","放射影像学","硕士"]
[70,"LECT2上调PPARγ促进脂质代谢增强肝再生的机制研究","YJS20230070",2245011416,"张慧","第一临床医学院（第一附属医院）","医学技术","硕士"]
[71,"饮食因素通过促进肝脏中性粒细胞的募集加重药物性肝损伤的研究","YJS20230071",2145011208,"周亮亮","第一临床医学院（第一附属医院）","肿瘤学","硕士"]
[72,"SPARCL1对动脉粥样硬化斑块形成的影响及分子机制初探","YJS20230072",2145011157,"程煦","第一临床医学院（第一附属医院）","外科学（胸心外）","硕士"]
[73,"人脐带间充质干细胞减轻酒精性肝损伤的机制研究","YJS20230073",2145011200,"怀千","第一临床医学院（第一附属医院）","肿瘤学","硕士"]
[74,"新型预后生物标志物MANF介导胶质瘤耐药的作用及免疫机制研究","YJS20230074",2145011159,"蔡华宝","第一临床医学院（第一附属医院）","外科学（神经外科）","硕士"]
[75,"动脉粥样斑块微环境中巨噬细胞铁死亡的异质性研究","YJS20230075",2245011192,"张炎","第一临床医学院（第一附属医院）","内科学（心血管病）","硕士"]
[76,"精浆微环境中必需微量元素负荷状态与少弱畸精症发病风险及严重程度的关联研究","YJS20230076",2145011187,"尹涛","第一临床医学院（第一附属医院）","妇产科学","硕士"]
[77,"褪黑素通过抑制METTL3/NLRP3通路以抑制Th17细胞分化进而缓解慢性非细菌性前列腺炎的机制研究","YJS20230077",2145011151,"李晓玲","第一临床医学院（第一附属医院）","外科学（泌尿外）","硕士"]
[78,"微塑料对男性生殖功能的影响及机制研究","YJS20230078",2145011436,"杨文","第一临床医学院（第一附属医院）","妇产科学","硕士"]
[79,"基于多组学的方法预测小细胞肺癌的免疫治疗疗效","YJS20230079",2145011251,"韩芮","第一临床医学院（第一附属医院）","内科学（呼吸系病）","硕士"]
[80,"急性髂股静脉血栓清除术后髂股静脉支架植入时机的研究：基于数据库的两阶段前瞻性非随机对照研究","YJS20230080",2245011574,"洪源","第一临床医学院（第一附属医院）","外科学（普外）","硕士"]
[81,"HDAC3通过介导μ阿片受体组蛋白去乙酰化修饰调控交感神经活性和心肌梗死后重塑","YJS20230081",2145011572,"毛遂","第二临床医学院（第二附属医院）","麻醉学","硕士"]
[82,"m6A阅读蛋白YTHDF1介导Drp1调控线粒体裂变在心肌纤维化发病中的分子机制","YJS20230082",2145011553,"涂彬","第二临床医学院（第二附属医院）","外科学（胸心外）","硕士"]
[83,"m6A甲基转移酶WTAP调控心肌成纤维细胞脂代谢重编程在糖尿病心肌病中的分子机制研究","YJS20230083",2145011552,"宋凯","第二临床医学院（第二附属医院）","外科学（胸心外）","硕士"]
[84,"细胞骨架关联蛋白2（CKAP2L）调控骨肉瘤细胞增殖与迁移的作用及机制研究","YJS20230084",2245011994,"张文彪","第二临床医学院（第二附属医院）","外科学","硕士"]
[85,"SGLT2抑制剂卡格列净对高糖环境下H9c2心肌细胞缺血再灌注损伤的线粒体SDH功能的相关机制研究","YJS20230085",2145011585,"张义君","第二临床医学院（第二附属医院）","急诊医学","硕士"]
[86,"催产素系统在乳腺癌患者和小鼠模型的心理韧性的塑造与调控中的作用及机制研究","YJS20230086",2145011759,"刘绍春","第二临床医学院（第二附属医院）","肿瘤学","硕士"]
[87,"TSG-6/PI3K/AKT通路在甲状腺相关性眼病中发挥抗纤维化和抑制脂肪生成的作用及其机制研究 ","YJS20230087",2145011723,"何秀慧","第二临床医学院（第二附属医院）","眼科学","硕士"]
[88,"腹壁戳孔局麻药注射套件在单孔腹腔镜胆囊切除术中的应用","YJS20230088",2145011982,"杨娜","第三附属医院（合肥市第一人民医院）","麻醉学","硕士"]
[89,"孕晚期睡眠剥夺对老年期子代CD-1小鼠认知的影响及其机制的研究","YJS20230089",2145011797,"危如梦","巢湖临床医学院（附属巢湖医院）","神经病学","硕士"]
[90,"基于机器学习算法预测老年人髋部骨折后一年死亡的预测模型的构建和验证","YJS20230090",2145011860,"郭佳乐","巢湖临床医学院（附属巢湖医院）","骨科学","硕士"]
[91,"LncRNA SCAT1在胃癌发生发展中的作用及机制研究","YJS20230091",2145011786,"黄杨","安徽省公共卫生临床中心（第一附属医院北区）","外科学","硕士"]
[92,"2型糖尿病合并勃起功能障碍与维生素D的关系及相关危险因素分析","YJS20230092",2245012453,"杨楠惠","附属安庆第一人民医院（安庆市第一人民医院）","内科学（内分泌与代谢病）","硕士"]
[93,"透明质酸联合微骨折治疗软骨缺损在兔模型中的实验研究","YJS20230093",2245012459,"梁洋洋","附属亳州医院（亳州市人民医院）","骨科学","硕士"]
[94,"SWE对脑卒中偏瘫患者肌张力和肌肉硬度的定量评估价值","YJS20230094",2145012018,"赵梦茹","附属合肥医院（合肥市第二人民医院）","超声医学","硕士"]
[95,"鉴定新的铜死亡相关lncRNA特征以预测子宫内膜癌患者的预后和免疫微环境","YJS20230095",2145012063,"姜稀雅","附属妇幼保健院（省妇幼保健院）","妇产科学","硕士"]
[96,"多时点唾液胃蛋白酶检测诊断咽喉反流的最佳时间点及对其对治疗的预测价值探究","YJS20230096",2145012161,"刘志","海军临床学院（解放军总医院第六医学中心）","耳鼻咽喉科学","硕士"]
[97,"基于单细胞测序探索HES1与NOTCH通路在人皮肤成纤维细胞衰老的作用机制","YJS20230097",2145012173,"王耀群","上海皮肤病临床学院（上海市皮肤病医院）","皮肤病与性病学","硕士"]
[98,"蟾毒灵抑制乏氧状态下的乳酸代谢调节 M2 型巨噬细胞极化抗结肠癌转移的机制研究","YJS20230098",2145012241,"唐东豪","上海普陀中心临床学院（普陀区中心医院）","外科学","硕士"]
[99,"通过二次感染模型对脓毒症小鼠长期免疫抑制的研究","YJS20230099","2145012134","秦泉","解放军306临床学院（战略支援部队特色医学中心）","外科学","硕士"]